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Actinic keratopathy (also called spheroidal degeneration or climatic droplet keratopathy). A, Gross appearance of the corneal button. The air bubbles are artifacts. B, Histology shows lightly staining basophilic globules (arrows) in the epithelium and superficial stroma. | Courtesy of Hans E. Grossniklaus, MD. © 2017 American Academy of Ophthalmology