MRI of the brain (T2 (A) and FLAIR (C) images; T1 with gadolinium (B, D)) of a patient with AMN who rapidly deteriorated clinically with new symptoms of cognitive decline. On MRI extensive white matter changes were seen in the parieto-occipital white matter and corpus callosum (A), but no enhancement of the lesion after administration of gadolinium (B). A follow-up MRI about 3 months later shows progression of the white matter lesion (C) and there is now faint enhancement of the rim of the lesion after gadolinium administration (D). | Engelen, M., Kemp, S., de Visser, M., van Geel, B. M., Wanders, R. J. A., Aubourg, P., & Poll-The, B. T. (2012). X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management. Orphanet Journal of Rare Diseases, 7(1), 51. https://doi.org/10.1186/1750-1172-7-51

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