Schematic approach to a patient with suspected RS: Signs and symptoms suspicious for transformation include: B-type symptoms (weight loss, night sweats, and fever), rapid enlargement of lymph nodes or spleen, hypercalcemia, and increased lactate dehydrogenase. ABVD, doxorubicin, bleomycin, vinblastine, and dacarbazine. | Parikh, S. A., Kay, N. E., & Shanafelt, T. D. (2014). How we treat Richter syndrome. Blood, 123(11), 1647–1657. https://doi.org/10.1182/blood-2013-11-516229

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