Acute and transient psychotic disorder (ATPD)

Characterized by acute onset of psychotic symptoms that emerge band reach their maximal severity within 2 weeks. Associated with recurrent episodes (35–45% cases) Classification International Classification of Diseases (ICD) classification: ICD-10 code Diagnostic subcategory of ATPD (F23) Duration, months F23.0 Acute polymorphic psychotic disorder without symptoms of schizophrenia <3 F23.1 Acute polymorphic psychotic disorder with…

Salmonella gastroenteritis (food poisoning)

Worldwide: One of the M/C causes of diarrhoea Europe: 2nd M/C foodborne disease after campylobacteriosis Aetiopathology     Cilnical features 12-36 hours after exposure, bacteria multiply in the small intestine, causing an intestinal inflammation (enteritis) with symptoms lasting from 2-7 days Diarrhoea (watery and non-bloody but may be mucoid and bloody) Fever Abdominal cramps Vomiting…

Differentiation syndrome

Introduction Differentiation syndrome, previously retinoic acid syndrome (RAS) or ATRA syndrome, is a potentially life-threatening complication in patients with acute promyelocytic leukemia (aPML) and associated with all-trans retinoic acid (ATRA) ‘tretinoin’ and arsenic trioxide use. Clinical features Common symptoms: Respiratory distress & fever (> 80% cases) Pulmonary infiltrates & pulmonary oedema (> 50% cases) Weight…

Acute promyelocytic leukaemia (aPML)

Subset of acute myeloid leukemia characterized by the fusion gene transcript PML-RAR-α and is now the most frequently curable acute leukemia in adults if promptly diagnosed and adequately treated.