a | Microscopic features of the normal germinal centre environment. Three stains simultaneously detect different proteins in formalin-fixed, paraffin-embedded sections of a reactive lymph node. Triple staining for CD20 (teal), CD3 (purple) and Ki67 (yellow, indicating proliferation) cells shows the topographic relationship between CD3+ T cells, CD20+ B cells, and Ki67+ follicular cells. Ki67+ cells co-express CD20. Magnification ×20. b | Multiplexed immunohistochemistry shows that the neoplastic nodules are composed of CD20+ B cells (teal). CD3+ T cells (purple) are mainly interfollicular, whereas Ki67+ cells (yellow) are within the follicles and co-express CD20. Magnification ×10. | Carbone, A., Roulland, S., Gloghini, A., Younes, A., von Keudell, G., López-Guillermo, A., & Fitzgibbon, J. (2019). Follicular lymphoma. Nature Reviews Disease Primers, 5(1), 83. https://doi.org/10.1038/s41572-019-0132-x

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