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A proposed algorithm based on expert opinion: Diagnosis usually depends on a combination of compatible clinical findings, histological evidence of non-necrotizing granulomas (for example, in transbronchial biopsy samples or ultrasonography-guided transbronchial needle aspiration (EBUS-TNA) of mediastinal lymph nodes) and exclusion of alternative causes of granulomas that result in a similar histological or clinical pattern. Bronchoalveolar lavage (BAL) with a typically increased CD4-positive (CD4+) T cell/CD8+ T cell ratio is supportive of a sarcoidosis diagnosis. | Judson, M. A. The diagnosis of sarcoidosis. Clin. Chest Med. 29, 415–427 (2008).

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