Group of disorders characterized by a premature RBC destruction that exceeds the compensatory capacity of the bone marrow to increase RBC production and keep up with the loss.
Category: Hematological System
Premalignant, clonal plasma cell disorder, characterized by the presence of a monoclonal (M) protein, <10% clonal plasma cells in the bone marrow, and absence of multiple myeloma or related lymphoplasmacytic malignancies (LPMs).
Spectrum of progressively more severe monoclonal gammopathies characterized by the expansion of a population of monoclonal bone-marrow plasma cells that produce monoclonal immunoglobulins.
Condition with life-threatening potential in which diminution of the oxygen-carrying capacity of circulating hemoglobin occurs due to conversion of some or all of the four iron species from the reduced ferrous [Fe2+] state to the oxidized ferric [Fe3+] state.