Paroxysmal nocturnal hemoglobinuria (PNH)

Rare, acquired chronic haemoglobinuria characterized by persistent intravascular hemolysis subject to recurrent exacerbations. Only hemolytic anemia caused by an acquired (rather than inherited) intrinsic defect in the cell membrane (deficiency of glycophosphatidylinositol leading to the absence of protective proteins on the membrane). History: While the term paroxysmal nocturnal hemoglobinuria (PNH) was introduced by Enneking in…

Deep vein thrombosis (DVT)

Subset of venous thromboembolism (VTE) in which blood clot forms in one of the larger, deeper veins that run through the muscles.

Disseminated intravascular coagulation (DIC)

Acquired clinicobiological syndrome characterized by widespread activation of coagulation leading to fibrin deposition in the vasculature, organ dysfunction, consumption of clotting factors and platelets, and life-threatening hemorrhage.

Thrombotic Thrombocytopenic Purpura (TTP)

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body.