Pseudoxanthoma elasticum (PXE)

Genetic metabolic disease (lack of functional ABCC6 protein) in which dystrophic calcification leads to cutaneous, ocular, cardiovascular and other manifestations

Acanthosis nigricans (AN)

Introduction Common cutaneous condition characterized by thick velvety hyperpigmented plaques of the intertriginous, flexural, and less commonly extensor areas of the skin. Aetiology Associated conditions: Disorders associated with insulin resistance (M/C) Obesity-associated AN (M/C type) Type 2 diabetes PCOS Internal malignancy Endocrine disorders Drug reactions Pathophysiology Clinical features Asymptomatic area of darkening and thickening of…

Lichen simplex chronicus (LSC)

Lichen simplex chronicus (LSC), also known as neurodermatitis, is a common chronic pruritic dermatitis characterized by lichenification of the skin caused by chronic itching and scratching.

Juvenile xanthogranuloma (JXG)

Rare benign fibrohistiocytic lesion and a type of granulomatous process most commonly on the skin. M/C non-Langerhans cell histiocytic (non-LCH) disorder of childhood History It was first described by HG Adamson in 1905. Later, in 1912, JER McDonagh described 5 new cases of the disease. In 1950s, Helwig and Hackney described 140 cases of the…