Necrotic retinal infection that results in irreversible vision loss.
M/C ocular opportunistic infection AIDS (25-42% cases in pre-HAART era)
M/C cause of vision loss in AIDS
Aetiology
AIDS CD4 levels < 50/mmc
Annual number of new cases of cytomegalovirus (CMV) retinitis at the Johns Hopkins Medical Institutions (JHMI). Informal surveys suggest that these data represent ~90% of the new cases of CMV retinitis in the Baltimore metropolitan area. | Jabs, D. A. (2011). Cytomegalovirus retinitis and the acquired immunodeficiency syndrome–bench to bedside: LXVII Edward Jackson Memorial Lecture. American Journal of Ophthalmology, 151(2), 198-216.e1. https://doi.org/10.1016/j.ajo.2010.10.018
Retinitis progression among patients with cytomegalovirus retinitis. | Jabs DA, Ahuja A, VanNatta M, Lyon A, Srivastava S, Gangaputra S for the Studies of the Ocular Complications of AIDS Research Group. Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: five-year outcomes.
Complications
Retinal detachment
Immune recovery uveitis (IRU):
After reconstitution of the immune system by HAART.
Immune recovery uveitis among patients with cytomegalovirus retinitis. | Jabs DA, Ahuja A, VanNatta M, Lyon A, Srivastava S, Gangaputra S for the Studies of the Ocular Complications of AIDS Research Group. Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: five-year outcomes.
