Internal Medicine

Drug fever (DF)

Febrile reaction induced by a drug without additional clinical features like skin eruption.

  • M/C occurs after 7-10 days of drug administration, persists as long as the drug is continued, disappears soon after stopping the drug, and will rapidly reappear if the drug is restarted.
  • Agents most commonly associated:
    • Penicillins, cephalosporins, antituberculars, quinidine, procainamide, methyldopa, and phenytoin.

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