Exocrine pancreatic insufficiency (EPI)

Exocrine pancreatic insufficiency (EPI)

Cover image: PIXOLOGICSTUDIO / Science Photo Library / Getty Images

 Introduction


Aetiology

Causes

  • Chronic pancreatitis
  • Genetic conditions:
    • Cystic fibrosis

Clinical Features

Malabsorbtion

Malnutrition

Weak bones, vision problems, easy bruising, skin rashes, weight loss

  • GASTRIC DISTURBANCES
    • Diarrhoea
    • Bloating
    • Flatulence
  • Steatorrhoea

Diagnosis

Investigations

  • STOOL EXAMINATION
    • Fat
    • Fecal elastase
  • Pancreatic Stimulation Testing
    • Use secretin
    • Expensive, so rarely performed

Treatment

No definitive treatment

Management principles

  • Lifestyle changes
    • Healthy lifestyle
    • Avoid risk factors
      • Smoking, alcohol, high-fat foods
    • Eat fruits & nutrient rich diet
  • Pancreatic insufficiency
    • PERT (Pancreatic enzyme replacement therapy)
      • Protease, amylase, lipase
  • Indigestion
    • Multivitamins & mineral supplements

INFOGRAPHIC_Pancreatic Insufficiency


 


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