f3.medium-2

Model of coronavirus replication. After receptor interaction and fusion of viral and plasma membranes, virus-specific RNA and proteins are synthesized, probably entirely in the cytoplasm. Expression of coronaviruses starts with translation of two polyproteins, pp1a and pp1ab, which undergo cotranslational proteolytic processing into the proteins that form the replicase complex. This complex is used to transcribe a 3′-coterminal set of nested subgenomic mRNAs, as well as genomic RNA, that have a common 5′ “leader” sequence derived from the 5′ end of the genome. Proteins are translated from the 5′ end of each mRNA. New virions are assembled by budding into intracellular membranes and released through vesicles by the cell secretory mechanisms. RER, rough endoplasmic reticulum; ER/GIC, endoplasmic reticulum/Golgi intermediate compartment. | Mani, H., & Jaffe, E. S. (2009). Hodgkin lymphoma: an update on its biology with new insights into classification. Clinical Lymphoma & Myeloma, 9(3), 206–216. https://doi.org/10.3816/CLM.2009.n.042

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