Rare autoimmune disease characterized by the triad of:

• Rheumatoid arthritis
• Splenomegaly
• Neutropenia

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History

The condition was named after its founder Augustus Roi Felty, after the doctor reportedly saw 5 patients in 1924 with a combination of conditions never before documented. The presence of chronic arthritis, splenomegaly, and leucopenia in all 5 patients prompted him to use his name to define the unknown syndrome.

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Clinical features

• S: Splenomegaly
• A: Anemia
• N: Neutropenia
• T: Thrombocytopenia
• A: Arthritis (rheumatoid)

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Complications

• Neutropenia:
  • Recurrent infections
• Splenomegaly:
  • Anaemia
  • Thrombocytopenia
• Lymphadenopathy
• Skin hyperpigmentation
• Cutaneous ulceration

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Diagnosis

Investigations

Complete blood count (CBC):

• Normochromic, normocytic anaemia
• Thrombocytopenia
• Neutropenia

Abnormal liver function tests (LFT)

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Management

Control the underlying rheumatoid arthritis.