Felty’s syndrome

Rare autoimmune disease characterized by the triad of:

  • Rheumatoid arthritis
  • Splenomegaly
  • Neutropenia


The condition was named after its founder Augustus Roi Felty, after the doctor reportedly saw 5 patients in 1924 with a combination of conditions never before documented. The presence of chronic arthritis, splenomegaly, and leucopenia in all 5 patients prompted him to use his name to define the unknown syndrome.

Clinical features

  • S: Splenomegaly
  • A: Anemia
  • N: Neutropenia
  • T: Thrombocytopenia
  • A: Arthritis (rheumatoid)


  • Neutropenia:
    • Recurrent infections
  • Splenomegaly:
    • Anaemia
    • Thrombocytopenia
  • Lymphadenopathy
  • Skin hyperpigmentation
  • Cutaneous ulceration



Complete blood count (CBC):

  • Normochromic, normocytic anaemia
  • Thrombocytopenia
  • Neutropenia

Abnormal liver function tests (LFT)


Control the underlying rheumatoid arthritis.

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