Benign condition characterized by recurrent episodes of jaundice.
- Autosomal recessive
- M/C inherited disorder of bilirubin metabolism leading to decreased glucuronidation of bilirubin
Gilbert’s syndrome was first described by French gastroenterologist Augustin Nicolas Gilbert and co-workers in 1901.
- Enzyme responsible for conjugation of glucuronic acid with bilirubin for the metabolism of bilirubin
- 10-35% reduction in the UGT1A1 enzyme activity. Patients manifest this syndrome only when they are generally homozygous for this mutation
- Triggering factors: Fasting, dehydration, inter-current illnesses, overexertion, stress, hemolysis or menstruation
No specific treatment required for patients with Gilbert syndrome as they are usually asymptomatic.