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Female Reproductive System ORGAN SYSTEMS

Hyperandrogenism

Endocrinal disorder of excessive levels of androgens (eg. testosterone) in the female body and the associated effects of the elevated androgen levels.

Introduction

Endocrinal disorder of excessive levels of androgens (eg. testosterone) in the female body and the associated effects of the elevated androgen levels.


Aetiology

  • Polycystic ovary syndrome (PCOS) (M/C)
  • Hyperthecosis and hyperinsulinemia
  • Cushing’s syndrome
  • Congenital adrenal hyperplasia
  • Tumours:
    • Adrenocortical carcinoma and tumours
    • Adenoma of the adrenal gland
    • Arrhenoblastoma
    • Hilar cell tumour
    • Krukenberg tumour
  • Menopause
  • Drug-induced hyperandrogenism
  • Heredity

Clinical features

  • Acne
  • Seborrhea (inflamed skin)
  • Hair loss on the scalp
  • Hirsutism
    • Increased body and/or facial hair
  • Elevated sex drive or libido
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Hirsutism and strias were shown in the patient with iatrogenic Cushing’s syndrome | By Ozlem Celik, Mutlu Niyazoglu, Hikmet Soylu and Pinar Kadioglu – http://mrmjournal.biomedcentral.com/articles/10.1186/2049-6958-7-26, CC BY 2.5, https://commons.wikimedia.org/w/index.php?curid=47877334

Case study

Physical examination:

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The Ferriman-Gallwey scoring system | Lara-Torre, E., & Hertweck, P. S. (2006). Medical Management of Gynecologic Problems in the Pediatric and Adolescent Patient. Clinical Gynecology. https://doi.org/10.1016/B978-0-443-06691-7.50037-6

Ultrasound (USG)


Management

  • Antiandrogens:
    • Cyproterone acetate
    • Flutamide
    • Spironolactone

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