Contents
Localized/disseminated lymphadenopathy and systemic symptoms characteristic of lymphoma
Aetiology
- Drug reaction: Phenytoin, Carbamazepine
- Immune disorders: Rheumatoid arthritis, systemic lupus erythematosus (SLE)
- Viral infections: Cytomegalovirus (CMV), Epstein-Barr virus (EBV)
- Bacterial infections: Cat-scratch disease
- Others:
- Castleman’s disease (HHV-8)
- Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)
- Lymphomatoid papulosis (Cutaneous lymphoproliferative disorder)
Clinical features
- Protracted fever (≥15 days)
- Alteration of the general status (asthenia, anorexia, and weight loss)
- Clinical lymphoproliferative syndrome:
- Lymphadenopathies with malignancy criteria (firm, fixed, or supracentimetric)
- Hepatomegaly
- Splenomegaly