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The schema of the proposed mechanism of PEL development: HHV8/KSHV-infected B cells acquire the characteristics of neoplastic change, such as immune evasion, drug resistance, antiapoptosis, cell cycle progression, and cytokine stabilization. | Color coding is as follows: viral proteins (light blue), transcription factors (lavender), kinase (light green), enzyme (blue), and proteins (magenta). | BCL10, B-cell lymphoma/leukemia 10; BCR, B-cell receptor; CARD11, caspase recruitment domain–containing protein 11; MALT1, mucosa-associated lymphoid tissue lymphoma translocation protein 1; TNFR, TNF receptor. | Illustration by Patrick Lane, ScEYEnce Studios. | Shimada, K., Hayakawa, F., & Kiyoi, H. (2018). Biology and management of primary effusion lymphoma. Blood, 132(18), 1879–1888. https://doi.org/10.1182/blood-2018-03-791426

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