Schematic diagram depicting the role of Cys-LT1 activation and mast cell activation in pathogenesis of aspirin exacerbated respiratory disease (AERD) symptoms. INF-γ—interferon-gamma; IL-4—interleukin-4; Cys-LT—cysteinyl-leukotriene; Cys-LT1—cysteinyl-leukotriene 1; LTC4—leukotriene C4; LTD4—leukotriene D4; LTE4—leukotriene E4; IL-33—interleukin-33; PGD2—prostaglandin D2. | Li, K. L., Lee, A. Y., & Abuzeid, W. M. (2019). Aspirin Exacerbated Respiratory Disease: Epidemiology, Pathophysiology, and Management. Medical sciences (Basel, Switzerland), 7(3), 45. doi:10.3390/medsci7030045

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