Microsoft Word – TAH419001.doc

Activated B-cell-like (ABC) diffuse large B-cell lymphomas (DLBCLs) are derived from plasmablasts that are characterized by a block in differentiation. ABC DLBCLs show constitutive activation of the oncogenic nuclear factor kappa B (NF-κB) signaling pathway as well as deregulation of the anti-apoptotic BCL2 protein. The molecular mechanisms by which NF-κB is activated will determine responsiveness to specific inhibitors. | Frick, M., Dörken, B., & Lenz, G. (2011). The molecular biology of diffuse large B-cell lymphoma. Therapeutic advances in hematology, 2(6), 369–379. doi:10.1177/2040620711419001