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Endocrine System

Multiple Endocrine Neoplasia (MEN)

Hereditary condition characterized by the occurrence of tumours involving two or more endocrine glands.

Hereditary condition characterized by the occurrence of tumours involving two or more endocrine glands.

  • Autosomal dominant (AD) inheritance for all forms

Classification

MEN 1 “Wermer syndrome”: Chromosome 11q13 

  • Characterized by parathyroid, pancreatic islet and anterior pituitary tumours

MEN2: Chromosome 10cen-10q11.2

  • Characterized by medullary thyroid carcinoma (MTC) in association with phaeochromocytoma
  • Clinical variants: MEN2A, MEN2B and MTC-only
Presentations of Multiple endocrine neoplasia
Presentations of Multiple endocrine neoplasia | Mikael Häggström – CC0, https://commons.wikimedia.org/w/index.php?curid=22692798

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