Hereditary condition characterized by the occurrence of tumours involving two or more endocrine glands.
- Autosomal dominant (AD) inheritance for all forms
Classification
MEN 1 “Wermer syndrome”: Chromosome 11q13
- Characterized by parathyroid, pancreatic islet and anterior pituitary tumours
MEN2: Chromosome 10cen-10q11.2
- Characterized by medullary thyroid carcinoma (MTC) in association with phaeochromocytoma
- Clinical variants: MEN2A, MEN2B and MTC-only
