Metabolism of arachidonic acid. Pathways of arachidonic acid metabolism involved in the pathogenesis of AERD. Enzymes are in italics, relevant receptors are in dashed boxes, and consequences of signaling through each receptor are in bulleted lists. Thick gray arrows show whether expression and function of each enzyme or product are increased or decreased in patients with AERD. | Laidlaw, T. M., & Boyce, J. A. (2013). Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunology and allergy clinics of North America, 33(2), 195–210. doi:10.1016/j.iac.2012.11.006

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