(a) Characteristic skin lesions on the predilection site on the neck, with yellowish papules coalescing into a plaque of inelastic and leathery skin. (b) Presence of angioid streaks. (c) Mineralization of the aortic valve revealed by echocardiography in a 6-year old patient and with PXE-like skin findings and cardiovascular involvement due to mutations in the ABCC6 gene | Guo H, Li Q, Chou DW, et al. Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6−/−) J Mol Med (Berl) 2013;91:1177–84.

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