MRI appearance of brain dysmorphology in myelomeningocele

MRI appearance of brain dysmorphology in myelomeningocele: Mid-sagittal MRI images of a typically developing child (parts a, d and g), a child with myelomeningocele and a hypoplastic corpus callosum (parts b, e and h) and a child with myelomeningocele and a hypogenetic corpus callosum (parts c, f and i). T1-weighted MRI images (parts a–c) that reveal a downward shift of the cerebellum (cb) in the children with spina bifida, representing the Chiari II malformation. Also note the tectal beaking (t) and the structural abnormalities in the corpus callosum (cc). Diffusion imaging tractography (parts d–i) showing connectivity emanating from the corpus callosum. This connectivity is divided into anterior (frontal; blue) and posterior (yellow) segments (parts g–i). Note the relative preservation of frontal connectivity in the individuals with spina bifida. There is a greater and more aberrant pattern of connectivity in the child with the hypogenetic corpus callosum. | K. Bradley (University of Houston, Texas, USA) and J. Juranek (University of Texas Health Science Center at Houston, USA).