Experiment supporting the concept that hypertension in pregnancy represents a uteroplacental response to ischemia

Experiment supporting the concept that hypertension in pregnancy represents a uteroplacental response to ischemia: a | In the Goldblatt model of renovascular hypertension, clamping the renal artery leads to development of hypertension through renal ischaemia in nonpregnant animals. b | By contrast, clamping the aorta below the renal arteries does not induce hypertension in nonpregnant animals. c | Aortic clamping in pregnant animals leads to hypertension. d | After hysterectomy, however, hypertension can no longer be elicited by aortic clamping, suggesting that the ischaemic pregnant uterus is the source of signals that lead to maternal systemic hypertension. Permission obtained from Semin. Perinatol. 12, Romero, R. et al. Toxemia: new concepts in an old disease, 302–323 © Elsevier (1988)