Can lead to secondary open-angle pigmentary glaucoma (PG)
Due to reduction of the outflow of aqueous humour and consequent increase in intraocular pressure leading to glaucomatous optic neuropathy
The released pigment granules are carried by aqueous convection currents and deposit on anterior segment structures including the corneal endothelium, iris surface, trabecular meshwork (TM), lens surfaces, and zonules. Accumulation of pigment in the TM may lead to increased resistance of aqueous humour outflow, and result in the development of pigmentary glaucoma (PG).
The defining characteristic of PDS is the bilateral shedding of pigment from the posterior iris pigment epithelium (IPE) and the subsequent deposition of this pigment in the anterior segment.
PDS is characterized by the presence of Krukenberg spindles, iris trans-illumination defects, trabecular meshwork pigmentation and backward bowing of the iris.