Preeclampsia is classically defined as the new onset of hypertension and proteinuria after 20 weeks of gestation. | Preeclampsia: Pathophysiology: Jorge Muniz, PA-C
Contents
Multisystem disorder of unknown aetiology characterised by the new-onset hypertension (≥ 140/90 mm-Hg) + proteinuria after the 20th week of pregnancy.
Hypertension + Proteinuria/end-organ damage
Features may appear before 20 in the case of:
Hydatiform mole
Acute polyhydramnios
Etiopathology
↑ Weight → Oedema ± HTN → Proteinuria
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Characterized by poor placental perfusion and a general disease process which may affect multiple organ systems.
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Effects on foetus:
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Diagnosis
Diagnostic criteria:
Hypertension
Oedema
Pitting oedema over tha ankles after 12 hours bed rest or rapid gain in weight of more than 1 pound
Proteinuria
Presence of total protein in 24-hours urine of more than 0.3g or more than or equal to 2+ (1.0g/l) on at least 2 random clean-catch urine samples tested more than or equal to 4 hours apart in the absence of UTI
Lab investigations:
Shorthand for laboratory values commonly used in pre-eclampsia. LDH=Lactate dehydrogenase, Uric acid=Uric acid, AST=Aspartate aminotransferase, ALT=Alanine aminotransferase, Plt=Platelets, Cr=Creatinine.