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Internal Medicine

Psittacosis “Parrot fever”

Psittacosis, also known as parrot fever, and ornithosis is a zoonotic infectious disease caused by a bacterium called Chlamydia psittaci and contracted from infected parrots, such as macaws, cockatiels and budgerigars, and pigeons, sparrows, ducks, hens, gulls and many other species of bird.

Psittacosis, also known as parrot fever, and ornithosis is a zoonotic infectious disease caused by a bacterium called Chlamydia psittaci and contracted from infected parrots, such as macaws, cockatiels and budgerigars, and pigeons, sparrows, ducks, hens, gulls and many other species of bird.


Clinical features

Incubation period: 5–19 days

First week:

  • Symptoms mimic typhoid fever:
    • Prostrating high fevers
    • Joint pains
    • Diarrhoea
    • Conjunctivitis
    • Epistaxis
    • Horder’s spots (like rose spots)
  • By the end of first week:
    • Respiratory infection + splenomegaly and/or epistaxis (SUGGESTIVE OF PSITTACOSIS)
    • Headache (can be so severe that it suggests meningitis)
    • Nuchal rigidity
    • Severe cases:
      • Stupor or coma

Second week:

  • Akin to acute bacteremic pneumococcal pneumonia:
    • Continuous high fevers
    • Headaches
    • Cough
    • Dyspnea
  • X-rays: patchy infiltrates or diffuse whiteout of lung fields

Complications

  • Endocarditis
  • Hepatitis
  • Myocarditis
  • Arthritis
  • Keratoconjunctivitis (occasionally extranodal marginal zone lymphoma of the lacrimal gland/orbit)
  • Neurologic complications (encephalitis)
  • Severe pneumonia
  • Death (< 1% cases)

Diagnosis

Blood panel:

  • Leukopenia
  • Thrombocytopenia
  • Moderately elevated liver enzymes

Microbiological cultures:

  •  BAL (bronchoalveolar lavage) fluid:
    • Leventhal-Cole-Lillie bodies (typical inclusion bodies) + macrophages
640px-chlamydophila_psittaci_fa_stain
Direct fluorescent antibody stain of a mouse brain impression smear showing C. psittaci. | CDC/Dr. Vester Lewis – This media comes from the Centers for Disease Control and Prevention’s Public Health Image Library (PHIL) #3792. Public Domain, https://commons.wikimedia.org/w/index.php?curid=2227979

Differential diagnosis:

  • Typhus
  • Typhoid
  • Atypical pneumonia by Mycoplasma
  • Legionella
  • Q fever

Management

Antibiotics

  • Tetracyclines and chloramphenicol (DOC)

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