Hirschsprung disease

Congenital megacolon characterized by lack of ganglion cells/enteric nervous plexuses (Auerbach and Meissner plexuses) in distal segment of colon.

Thyroglossal duct cysts

Anterior midline neck mass (fibrous cyst) that moves with swallowing or protrusion of the tongue that forms from a persistent thyroglossal duct.

Neural tube defects (NTDs)

Severe birth defects of the central nervous system that originate during embryonic development when the neural tube fails to close completely.