Paroxysmal nocturnal hemoglobinuria (PNH)

Rare, acquired chronic haemoglobinuria characterized by persistent intravascular hemolysis subject to recurrent exacerbations. Only hemolytic anemia caused by an acquired (rather than inherited) intrinsic defect in the cell membrane (deficiency of glycophosphatidylinositol leading to the absence of protective proteins on the membrane). History: While the term paroxysmal nocturnal hemoglobinuria (PNH) was introduced by Enneking in…

Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Inborn error of metabolism that predisposes to hemolysis and resultant jaundice in response to a number of triggers, such as certain foods, illness, or medication.