Contents
Genetic condition affecting the complement membrane attack complex (MAC) (C5-C9).
- High risk of Neisseria infection
Diagnosis
Differential diagnosis
| C4 (C) | FB (A) | C3 | CH50 | Conditions |
|---|---|---|---|---|
| · | ↓ | ↓ | ↓ | PSGN, C3 NeF AA |
| ↓ | · | ↓ | · | HAE, C4D |
| · | · | · | ↓ | TCPD |
| ↓ | · /↓ | ↓ | ↓ | SLE |
| ↑ | ↑ | ↑ | ↑ | inflammation |
- (C): Classic pathway
- (A): Alternate pathway
- PSGN: Post-streptococcal glomerulonephritis
- C3 NeF AA: C3 Nephritic factor autoantibody
- HAE: Hereditary angioedema
- C4D: Complement 4 deficiency
Management
- Meningococcal and pneumococcal vaccinations
Summary