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Internal Medicine

Terminal complement pathway deficiency (TCPD)

Genetic condition affecting the complement membrane attack complex (MAC) (C5-C9).

  • High risk of Neisseria infection
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Membrane Attack Complex (Terminal Complement Complex C5b-9) | SLiva2016 – CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=45952238

Diagnosis

Differential diagnosis

C4 (C) FB (A) C3 CH50 Conditions
 · PSGN, C3 NeF AA
 ·  · HAE, C4D
 ·  ·  · TCPD
 · /↓ SLE
inflammation
  • (C): Classic pathway
  • (A): Alternate pathway
  • PSGNPost-streptococcal glomerulonephritis
  • C3 NeF AAC3 Nephritic factor autoantibody
  • HAE: Hereditary angioedema
  • C4DComplement 4 deficiency

Management

  • Meningococcal and pneumococcal vaccinations

Summary

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