Integumentary system ORGAN SYSTEMS

Epidermodysplasia verruciformis (EV) “Treeman syndrome”

Epidermodysplasia verruciformis (EV) “treeman syndrome” or Lewandowsky–Lutz dysplasia, is an extremely rare autosomal recessive hereditary skin disorder associated with an abnormal susceptibility to human papillomaviruses (HPVs) of the skin and a high risk of skin cancer.

  • Resulting uncontrolled HPV infections result in the growth of scaly macules and papules, particularly on the hands and feet.
  • Typically associated with HPV types 5 & 8 (present in 80% normal population as asymptomatic infections)
  • Onset 1-20 years


Felix Lewandowsky was a German dermatologist, who had studied the disease and described it prior to his death. Wilhelm Lutz eventually believed that the disease was due to a certain overgrowth of skin cells after Lewandowsky’s death. However, later in 1939, two other men named Maurice Sullivan and Frances Ellis documented how the disease was connected to a different type of disease known as human papillomavirus (or HPV), which leads to much of what we now know today.

Case studies:

  • Abul Bajandar



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