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Ocular System

Cornea verticillata

Cornea verticillata, also called vortex keratopathy, whorl keratopathy, or Fleischer vortex is a whorl-like pattern of golden brown or gray opacities in the cornea.

Cornea verticillata: A bilateral, whorl-like corneal pattern of cream colored lines in a patient with Fabry disease. | Alessandro P Burlina, Katherine B Sims, Juan M Politei, Gary J Bennett, Ralf Baron, Claudia Sommer, Anette Torvin Møller and Max J Hilz - Alessandro P Burlina, Katherine B Sims, Juan M Politei, Gary J Bennett, Ralf Baron, Claudia Sommer, Anette Torvin Møller and Max J Hilz: Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel. In: BMC Neurology 2011, 11:61 doi:10.1186/1471-2377-11-61

Cornea verticillata, also called vortex keratopathy, whorl keratopathy, or Fleischer vortex is a whorl-like pattern of golden brown or gray opacities in the cornea.

Aetiology

M/C causes:

  • Amiodarone
  • Fabry disease

Pharmacologic associations:

  • Chloroquine and Hydroxychloroquine
  • Indomethacin
  • Phenothiazines

Non-pharmacologic aetiologies:

  • Multiple myeloma (MM)
  • Neurotrophic keratitis
  • Lisch corneal dystrophy
  • Epidemic keratoconjunctivitis
  • Iron deposition (i.e., after radial keratotomy)
  • Stromal deposition (gold, silver, antacid, retinoid depositions)

Clinical features

  • Fine golden-brown or gray opacities in the basal epithelium that branch out from a central whorl, usually across the inferior cornea (no visual disturbance)

Management

No recommended treatment

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