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In situ follicular neoplasia: Tumour progression from in situ follicular neoplasia to early follicular lymphoma (FL) or overt FL. a | The strongly immunostained BCL2+ B cells are confined to the germinal centre. The BCL2 staining in this population is more intense than that exhibited by the surrounding mantle cells. Magnification ×20. b | A lymph node displaying overt FL and early FL. Magnification ×0.2. c | Foci of early FL in which BCL2+ cells expand outside the follicle without a defined mantle zone. Magnification ×2. d | Foci of overt FL showing intense immunostaining of BCL2 within the neoplastic follicle. Magnification ×2. All panels are of formalin-fixed, paraffin-embedded tissue sections. | Carbone, A., Roulland, S., Gloghini, A., Younes, A., von Keudell, G., López-Guillermo, A., & Fitzgibbon, J. (2019). Follicular lymphoma. Nature Reviews Disease Primers, 5(1), 83. https://doi.org/10.1038/s41572-019-0132-x